Multiple Myeloma Regression Mediated by Bruceantin

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Multiple myeloma regression mediated by bruceantin.

PURPOSE Bruceantin has been shown to induce cell differentiation in a number of leukemia and lymphoma cell lines. It also down-regulated c-MYC, suggesting a correlation of down-regulation with induction of cell differentiation or cell death. In the present study, we focused on multiple myeloma, using the RPMI 8226 cell line as a model. EXPERIMENTAL DESIGN The effects of bruceantin on c-MYC le...

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ژورنال

عنوان ژورنال: Clinical Cancer Research

سال: 2004

ISSN: 1078-0432,1557-3265

DOI: 10.1158/1078-0432.ccr-0362-3